The analysis demonstrated that adolescent girls and young women with the higher vulnerability profiles, including the impact of unequal gender norms, have increased odds of negative health outcomes and experiences. The analysis calls upon tailoring community-based HIV prevention efforts by deferentially targeting/tailoring interventions and health services for sub-populations in higher versus lower HIV vulnerability profiles. Across the three country contexts (eight study sites across Kenya, Malawi and Zambia that are part of the PEPFAR-DREAMS), having gender inequitable attitudes and no comprehensive knowledge about HIV were consistently associated with the higher vulnerability profile. The prominent influence of these factors in defining the higher vulnerability profile across all three contexts may mean that these may be essential elements for HIV prevention programming to focus on/consider