This paper summarizes the results from an experiment conducted with unmarried young women aged 15-21 in rural southern Malawi, during which respondents were randomly assigned to either an audio computer-assisted self-interview or a conventional face-to-face interview. In addition, biomarkers were collected for HIV and three STIs: gonorrhea, chlamydia, and trichomoniasis. Before collecting the biomarkers, nurses conducted a brief face-to-face interview with participants in which they repeated questions about sexual behavior asked earlier.