Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women

Publish Year : 2016
Publisher : New England Journal of Medicine
Author Name : Nel A., van Niekerk N., Kapiga S., Bekker L.G., Gama C., Gill K., Kamali A., Kotze P., Louw C., Mabude Z., Miti N., Kusemererwa S., Tempelman H., Carstens H., Devlin B., Isaacs M., Malherbe M., Mans W., Nuttall J., Russell M., Ntshele S., Smit M., Solai L., Spence P., Steytler J., Windle K., Borremans M., Resseler S., Van Roey J., Parys W., Vangeneugden T., Van Baelen B., and Rosenberg Z.
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Description :

This article evaluates the safety and efficacy of a vaginal ring containing dapivirine for the prevention of HIV infection in nearly 2,000 women of reproductive age from South Africa and Uganda. The study was a randomized, double-blind, placebo-controlled trial and it found that the dapivirine ring was not associated with any safety concerns and was associated with a lower rate of HIV-1 infection than the placebo rate.

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