The Society for Adolescent Medicine notes progress in the scientific understanding of the diagnosis and treatment of HIV. Likewise advances have been made in the prevention of perinatal transmission of HIV. However, SAM notes that great challenges still exist for those working to prevent HIV/AIDS in adolescents and young adults and to provide treatment, care and support for those who already are infected. This document updates the position of the Society for Adolescent Medicine regarding HIV infection and AIDS in adolescents.