Data from the Minnesota Department of Health HIV/AIDS Surveillance Report (2015) show that African-born women continue to be disproportionately affected by HIV. In 2015, these women accounted for more than half (54%) of all new cases of HIV reported among females in Minnesota and 34% of all known female cases in the state.The primary objective of this study was to gain an insight into the strategies that will limit the spread of HIV infection and enhance HIV care among African-born immigrants. Findings suggest that gender-specific sociocultural factors, such as intimate partner violence, gender-based stigma, discriminatory cultural beliefs, drive HIV and constitute barriers to HIV treatment.