Adolescents are one sixth of the world's population and account for 6% of the world's global burden of disease and injury. Over 3,000 adolescents die every day from largely preventable causes. In 2015, the top causes of adolescent girls' included HIV/AIDS and maternal conditions. This guidance assists governments to support country implementation to improve the health of their adolescents through evidence, case studies, a summary document, a comic book, brochure and infographics. 

Sections on disease burdens of sexual and reproductive health and HIV and related, evidence-based interventions are included as well as gender transformative approaches in national programming for adolescents' health.