This publication compiles and summarizes evidence to support successful interventions in HIV programming for women and girls. This is a comprehensive review, spanning 2,000 articles and reports with data from more than 90 countries, that highlights a number of interventions for which there is substantial evidence of success: from prevention, treatment, care and support to strengthening the enabling environment for policies and programming. It highlights gaps in programming that remain. It is meant for national AIDS programs, government ministries, implementing partners, donors, civil society groups and others that need an easy to understand format for identifying what works for women.